The issue of space debris poses challenges not only in technical, but also legal, political and economic dimensions. A sustainable solution needs to take into account all of them. This paper investigates such a potential solution in a multidisciplinary approach. To this end, it addresses the effectiveness of the existing debris mitigation guidelines, and identifies technical improvements for mitigation. It continues examining technical concepts for debris removal and performing proper cost-benefit trade-offs. The results of new simulations to assess the damage cost caused by space debris are presented. Based on these findings, an organizational framework and political recommendations are developed which will enable a sustainable use of space starting in 2020. The findings are compiled into a roadmap, which outlines 1) a path to the full adherence to debris mitigation guidelines and 2) the removal of ten large pieces of debris per year by a dedicated international organization, including expected expenditures necessary for its implementation.